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The Effects of Tranquillization:
Benzodiazepine Use in Canada

Health Canada Publication: 1982

8. APPENDIX A

BENZODIAZEPINES SOLD IN CANADA, 1981

Generic Name Canadian Trade Names
(Manufacturer)
Date of
Introduction
chlordiazepoxide
  hydrochloride

methaminodiazepoxide
  hydrochloride
Corax (ICN)
C Tran (Beecham)
Librium (Roche)
Medilium (Medic)
Novopoxide (Novopharm)
Relaxil (Maney)
Relium (Riva)
Solium (Horner)
Trilium (Trianon)
also generically by:
(Drug Trading); (Duchesnay); (Interlab);
(Pro Doc); (Québec Pharmaceutiques);
(Sands)
1960
clonazepam Rivotril (Roche)
1976
clorazepate
  dipotassium
Tranxene (Roche)
1973
diazepam D Tran (Beecham)
E Pam (ICN)
Meval (Medic)
Neo Calme (Neo)
Novodipam (Novopharm)
Rival (Riva)
Stress-Pam (Sabex)
Valium (Roche)
Vivol (Horner)
also generically by:
(Drug Trading); (Pro Doc);
(Québec Pharmaceutiques); (Sands)
1962
flurazepam
  hydrochloride
Dalmane (Roche)
Novoflupam (Novopharm)
1970
flurazepam
  monohydrochloride
Somnol (Horner)
1981
lorazepam Ativan (Wyeth)
1977
nitrazepam Mogadon (Roche)
1981
oxazepam Apo Oxazepam (Apotex)
Ox-Pam (ICN)
Serax (Wyeth)
also generically by: (Drug Trading)
1965
temazepam Restoril (Anca)
1981
triazolam Halcion (Upjohn)
1980

Sources: Canadian Pharmaceutical Association. Compendium of Pharmaceuticals and Specialities. Sixteenth Edition, 1981, Health and Welfare Canada. Canadian Drug Identification Code. Seventh Edition, 1980.

9. APPENDIX B

GLOSSARY OF MEDICAL AND DRUG-RELATED TERMS

acetaminophen - (paracetamol), a mild pain reliever, which also reduces fever, e.g. Tylenol

adjunctive - adding to or accompanying in a subordinate category

anaesthetic - an agent that produces local or general loss of feeling or sensation

analgesic - a drug which relieves pain

angina - a disease marked by spasmodic attacks of intense suffocative pain

anticholinergic - a drug that blocks the effects of acetylcholine, a chemical produced naturally by the body and responsible for certain nervous system activities; these drugs inhibit the secretion of acid in the stomach, slow the passage of food through the digestive system, inhibit the production of saliva, sweat, and bronchial secretions, and increase the heart rate

antihistamine - a drug used to lessen or counteract the effects of histamine, a chemical produced by the body in response to various allergy-causing agents

antispasmodic - a drug used to quiet the spasms of voluntary and/or involuntary muscles, usually of the gastrointestinal tract

anxiolytic - a drug used to relieve anxiety

armamentarium - the entire equipment of a practitioner, such as medicines, instruments, books, etc.

ASA - acetylsalicylic acid, a mild pain reliever, e.g. Aspirin

barbiturates - derivatives of the barbituric acid, which produce central nervous system (CNS) depression, ranging from sedation to coma

clinical pharmacology - that aspect of pharmacology concerned with the study of drugs used in the prevention, diagnosis, and treatment of human disease

colitis - inflammation of the colon

contraindication - an indication, symptom, or condition that makes inadvisable a particular treatment or procedure

digit symbol substitution test - one of the 11 sub-tests of the Wechsler Adult Intelligence Scale. Performance on the test is taken as a measure of the efficiency of the processes of immediate rote recall, visual-motor integration, and visual imagery

efficacy - the power to produce an effect

epidemiology - science dealing with the incidence, distribution, and control of disease in a population

flicker fusion tests - particular tests used to assess the general state of arousal of the central nervous system

generic - nonproprietary; denoting a drug name not protected by a trademark; sometimes called 'public name'

hypnotic - an agent that dulls the senses or induces sleep

illicit - illegal

indication - a symptom or particular circumstance that indicates the advisability or necessity of a therapy

metabolism of drugs - all the processes involved in the utilization of drugs entering the body

metabolite - any substance produced by metabolism

methadone - a narcotic drug administered usually in the form of its bitter crystalline hydrochloride for the relief of pain, and usually used in the treatment of narcotic dependence

modality - any of several methods utilized in therapy

myocardial infarction - necrosis or death of a portion of the heart muscle, from interruption or curtailment of its blood supply

narcotic - a drug that in moderate doses relieves pain and induces profound sleep. It has a high potential for addiction leading to abuse

pathophysiology - the physiology of abnormal states, specifically the functional changes that accompany a particular syndrome or disease

pharmacology - study of the history, source, biochemical and physiological effects, mechanisms of action, absorption, distribution, biotransformation and excretion, therapeutic and other uses of drugs

precordial - situated or occurring in front of the heart; involving the precordium

psychosomatic - resulting from the influence of emotional stress or conflict on a predisposed somatic area, organ, or bodily system

psychotropic - as used in this document, refers only to those drugs sold on prescription which have the ability to modify mood, but does not include analgesics

sedative - an agent which allays activity and excitement, and has a calming effect. Sedatives/hypnotics are frequently referred to as one category in clinical practice since their effects can range from sedation to hypnosis depending on the dose given

serum - the fluid portion of the blood obtained after coagulation, distinguished from the circulating plasma in blood

somatic - pertaining to the body

tachycardia - excessively rapid heart rate

therapeutic - pertaining to the treatment of disease

trade name - a name used by a company to identify its product as a unique entity

tranquillizer - an agent which has a calming effect without impairing consciousness. Tranquillizers are usually divided into two groups, major and minor, although considerable confusion surrounds the use of these terms. Major tranquillizers are of use in treating serious disorders such as mania and schizophrenia and are often called anti-psychotic drugs. They also produce a neuroleptic state and are sometimes called neuroleptics. Minor tranquillizers were thus named to distinguish them from major tranquillizers, because they are not effective in serious psychological disorders. They are sometimes called anti-anxiety drugs or anxiolytics because they are used to treat patients suffering from anxiety. Alternatively, minor tranquillizers and sedatives are sometimes grouped together under the heading anxiolytic sedatives

vigilance tests - performance tasks designed to measure the level or state of readiness of the nervous system, and its ability to detect and respond to certain specified small changes occurring at random time intervals in the environment

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